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Updated: Jun 12, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Association of Weight Loss With Improvement in Metabolic Status Among People Eligible for the Specific Health
Masachika Nishikawa1, Yuta Suzuki1,2, Toshiyuki Ko1
1Department of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Background:
While international guidelines recommend 5-10% body weight reduction, evidence characterizing the dose-response relationship between specific weight loss amounts and metabolic syndrome (MetS) resolution in real-world populations is limited.
Methods And Results:
In this retrospective study, we analyzed a large-scale health check-up database provided by DeSC Healthcare (Tokyo, Japan). We identified 37,256 individuals with baseline MetS eligible for the Specific Health Guidance (SHG) program (2014-2023). Logistic regression assessed the association between 1-year weight changes and subsequent MetS status. Weight loss was significantly linked to MetS resolution. Compared with weight maintenance, a weight loss of 2.0-2.9 kg showed an adjusted odds ratio (OR) of 0.45 (95% confidence interval [CI] 0.41-0.49), and a loss of ≥3.0 kg showed an OR of 0.19 (95% CI 0.18-0.21). These associations were consistent across age and sex subgroups. Secondary analyses confirmed significant improvements in waist circumference, blood pressure, lipid profiles, and HbA1c.
Conclusions:
Weight loss over 1 year is significantly associated with MetS resolution among SHG-eligible individuals. These findings support the validity of weight loss recommendations in the fourth phase of the SHG program and offer empirical data for future health guidance design.
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