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Published on: September 26, 2013
Autosomal recessive human CTLA-4 deficiency with autoimmune infiltration
1Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
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This issue of the Journal of Human Immunity features a study (https://doi.org/10.70962/jhi.20250227) reporting the long-awaited first case of autosomal recessive human CTLA-4 deficiency. Here, the features of this patient are compared and contrasted to those in CTLA-4 haploinsufficient patients, patients treated with CTLA-4 inhibitors, and Ctla4 -/- mice.
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