Related Experiment Video
Updated: Jun 12, 2026
Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
Published on: May 23, 2025
Spatial variation of evoked potentials in porcine retinas characterized by multi electrode array upon stimulation via
Jesper Guldsmed Madsen1, Pratik Kusumanchi2, Toke Bek1
1Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark.
Introduction:
Visual restoration using photovoltaic retinal implants to alleviate vision loss has recently seen substantial progress. Most devices being developed are reliant upon rare earth metals, such as iridium, but their use in connection with highly immunoactive retinal tissue may pose an issue. Typical electrodes are fabricated as thin films and as such they are two-dimensional. Ideally, stimulating electrodes should be patterned into 3D topologies to optimize the electrode-tissue interface. It is currently not possible to achieve complex 3D electrode geometries with metal-based materials, which could potentially improve stimulation efficiency and resolution.
Methods:
This study utilizes multi electrode array analysis of the spatial variation of evoked potentials in porcine retinal explants stimulated electrically via newly developed 3D carbon electrodes.
Results:
Nine out of 10 explants showed significantly higher tissue activity during stimulation using the electrode, supplied with a direct current pulse with a voltage of +0.5 V typical for single-junction silicon photovoltaics.
Discussion:
We report no spatial biases or patterns in tissue activation. The electrode significantly activated tissue above spontaneous activity levels and did not produce spatial patterns or biases, confirming the electrode as an alternative for metallic electrodes and for further development and in vivo testing.
