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Related Concept Videos

Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
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The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
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Introduction to the Human Microbiota

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Related Experiment Videos

Causal Association Between Gut Microbiota, Plasma Metabolites, and Prostate Cancer: Two-Step Mendelian Randomization

Junxiong Li1, Jian Hou1, Haolin Liu2

  • 1Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Dose-Response : a Publication of International Hormesis Society
|June 11, 2026
PubMed
Summary

This study reveals how gut microbiota (GM) and its metabolites causally influence prostate cancer (PCa). Specific gut bacteria and metabolites are linked to PCa risk and protection, offering potential therapeutic targets.

Keywords:
gut microbiotamediation analysismendelian randomizationplasma metabolitesprostate cancer

Related Experiment Videos

Area of Science:

  • Microbiome research
  • Metabolomics
  • Cancer epidemiology

Background:

  • The interplay between gut microbiota (GM) and prostate cancer (PCa) is complex and not fully understood.
  • The specific role of metabolites in mediating the GM-PCa relationship requires further investigation.

Purpose of the Study:

  • To investigate the causal relationships between gut microbiota traits, plasma metabolites, and prostate cancer.
  • To identify specific metabolites that mediate the association between GM and PCa.

Main Methods:

  • Mendelian randomization (MR) analyses were employed, primarily using the inverse variance weighted (IVW) method.
  • MR-Egger, weighted median, and weighted mode methods were used for supplementary validation.
  • Mediation analysis was conducted to quantify the contribution of metabolites to the GM-PCa association.

Main Results:

  • Eighteen GM traits and 66 plasma metabolites demonstrated a causal association with PCa.
  • Specific bacteria like P_Firmicutes showed a protective effect, while Parasutterella increased risk.
  • Four metabolites, including N-acetylarginine and N-acetyl-L-glutamine, were found to mediate the causal effects of GM on PCa.

Conclusions:

  • Metabolite-mediated pathways link gut microbiota to prostate cancer.
  • These findings highlight potential novel biomarkers and therapeutic targets for precision medicine in PCa treatment.