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Case Report: dynamic monocyte reprogramming during ALSS therapy in type B HBV-ACLF revealed by single-cell

Jiale Xie1, Jiahua Liu1, Feiyu Wang2

  • 1Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, Shijiazhuang, Hebei, China.

Frontiers in Immunology
|June 11, 2026
PubMed
Summary

Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) treatment with artificial liver support systems (ALSS) reprogrammed monocytes. A pro-inflammatory monocyte subpopulation (Mono4) decreased, suggesting ALSS impacts systemic inflammation in HBV-ACLF patients.

Keywords:
HBV-related acute-on-chronic liver failureartificial liver support systemcase reportmonocytesingle-cell RNA sequencing

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