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Bone marrow-sparing radiotherapy in women with cervical cancer treated with radiochemotherapy
Farley Soares Cantidio1,2, Paulo Henrique Costa Diniz3,4, Gabriel Gil2
1Woman's Health, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Objectives:
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To evaluate the benefits and harms of bone marrow-sparing radiotherapy compared with non-bone marrow-sparing radiotherapy in women with locally advanced cervical cancer treated with concurrent chemoradiotherapy. Secondary objectives To investigate whether effects differ according to clinical, histopathological, and technical characteristics, focusing on: acute haematologic toxicity; acute gastrointestinal and genitourinary toxicity; and bone marrow dose-volume parameters associated with acute haematologic toxicity, including exploration of dose-volume ranges relevant for clinical implementation.
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