Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Dual-Factor Activatable Covalent Targeted Photoacoustic Imaging Probe for Tumor Imaging.

Angewandte Chemie (International ed. in English)·2024
Same author

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.

Cancer discovery·2023
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
09:43

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

Small-Molecule Targeted and Activatable Photoacoustic Probes for In Vivo Imaging: Design Principles and Recent

Jiho Song1, Jae Won Chang1,2,3

  • 1Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

Targeted and activatable photoacoustic (PA) probes enhance in vivo molecular imaging by improving contrast and reducing background signals. These advanced probes offer greater precision for visualizing biological events deep within tissues.

Keywords:
activatablein vivo imagingphotoacoustic imagingsmall‐moleculetargeted

More Related Videos

Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
10:17

Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging

Published on: June 26, 2017

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
09:56

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Related Experiment Videos

Last Updated: Jun 12, 2026

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
09:43

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
10:17

Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging

Published on: June 26, 2017

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
09:56

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Area of Science:

  • Biomedical Imaging
  • Molecular Imaging
  • Nanotechnology

Background:

  • Photoacoustic (PA) imaging combines optical contrast with ultrasound's deep-tissue penetration.
  • Exogenous contrast agents improve PA imaging depth and resolution.
  • Endogenous chromophore signals limit PA imaging contrast.

Purpose of the Study:

  • To review photoacoustic probes integrating targeted and activatable designs.
  • To highlight strategies for enhancing in vivo PA imaging contrast.
  • To discuss future directions for PA probe development.

Main Methods:

  • Review of targeted probe designs utilizing disease- or tissue-associated receptors, transporters, and enzymes.
  • Analysis of activatable probe mechanisms responding to biological environments or biomarkers.
  • Evaluation of recent advances in in vivo PA imaging performance.

Main Results:

  • Targeted designs promote selective accumulation of PA probes.
  • Activatable designs enable analyte- or enzyme-responsive signal generation.
  • Integrated probes demonstrate enhanced in vivo imaging capabilities.

Conclusions:

  • Targeted and activatable PA probes significantly improve in vivo molecular imaging contrast.
  • These probes offer versatile tools for precise visualization of biological processes.
  • Further development is needed to overcome current challenges and optimize future applications.