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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Jun 12, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Therapeutic vitrectomy for non-infectious uveitis.

Francesco Sabatino1,2, Hakim-Moulay Dehbi3, Carlos Pavesio3,4

  • 1Vitreoretinal Service, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.

The Cochrane Database of Systematic Reviews
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

This review evaluates pars plana vitrectomy (PPV) versus medical therapy alone for non-infectious uveitis. It assesses benefits and harms in persistent inflammation or cystoid macular oedema (CMO).

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Area of Science:

  • Ophthalmology
  • Surgical Interventions
  • Inflammatory Eye Diseases

Background:

  • Non-infectious intermediate, posterior, or panuveitis can cause persistent inflammation and cystoid macular oedema (CMO).
  • Standard treatment involves medical therapy, but outcomes in complicated cases require further evaluation.
  • Pars plana vitrectomy (PPV) is a surgical option for refractory uveitis.

Purpose of the Study:

  • To evaluate the benefits and harms of pars plana vitrectomy (PPV), with or without adjunctive medical therapy, compared with medical therapy alone.
  • To assess PPV's efficacy in non-infectious intermediate uveitis, posterior uveitis, or panuveitis.
  • To determine the impact of PPV on persistent inflammation and cystoid macular oedema (CMO).

Main Methods:

  • This is a protocol for a Cochrane Review of interventions.
  • The review will compare PPV (with or without medical therapy) against medical therapy alone.
  • Systematic review methodology will be employed to synthesize evidence.

Main Results:

  • Evidence synthesis is pending completion of the review.
  • The review aims to identify comparative effectiveness and safety data.
  • Specific outcomes will include visual acuity, intraocular inflammation, macular oedema, and adverse events.

Conclusions:

  • The findings will inform clinical decision-making for managing complex non-infectious uveitis.
  • This review will provide evidence on the role of PPV in improving outcomes for patients with persistent inflammation or CMO.
  • Understanding the risk-benefit profile of PPV is crucial for optimizing treatment strategies.