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Updated: Jun 12, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Dynamic microclot profiling: thromboelastography advances precision management in long COVID and myalgic

Shafaq Saleem1, Ahmad Hussain2, Muhammad Haroon1

  • 1Department of Medicine, Rawalpindi Medical University, Rawalpindi.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|June 11, 2026
PubMed

Insights

Persistent microclots contribute to Long COVID and ME/CFS pathophysiology. Thromboelastography (TEG) shows promise for diagnosing these coagulation abnormalities, guiding future precision therapeutics.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Immunology

Background:

  • Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share overlapping symptoms.
  • Emerging evidence suggests persistent fibrinoid microclots impair microcirculation in these conditions.

Purpose of the Study:

  • To review the role of microclots in Long COVID and ME/CFS.
  • To evaluate thromboelastography (TEG) as a diagnostic tool for these microclot-associated conditions.

Main Methods:

  • Comprehensive literature review of biomedical databases.
  • Analysis of studies reporting microclot prevalence and TEG profiles in Long COVID and ME/CFS patients.

Main Results:

  • Microclots are prevalent in both Long COVID and ME/CFS.
  • TEG analysis reveals increased clot strength and reduced fibrinolysis in Long COVID, indicating hypercoagulability.
  • TEG interpretation challenges include preanalytical variability and lack of standardized protocols.

Conclusions:

  • Persistent microclots are a key pathophysiological feature of Long COVID and ME/CFS.
  • TEG offers a promising approach for detecting coagulation abnormalities and guiding treatment.
  • Standardization of TEG protocols and integration with multiomics biomarkers are crucial for advancing precision therapeutics and improving patient outcomes.

Keywords:
anticoagulationlong coronavirus diseasemicroclotsmyalgic encephalomyelitis/chronic fatigue syndromethromboelastography

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