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![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Tetrahydroxydiboron-Driven Photocatalytic Three-Component Reductive Petasis Reaction
Weibin Xie1, Wei Wei1, Shihui Wang2
1State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Abstract:
N-arylated-α-amino acid derivatives are the core structures of many important molecules. Herein, we report the tetrahydroxydiboron-driven photocatalytic three-component reductive Petasis reaction of aryl amines, glyoxalates and activated esters of aliphatic acids under mild conditions with broad substrate scope. Mechanistic studies show that tetrahydroxydiboron is used as a convenient reducing agent to generate alkyl radicals from activated esters and subsequent addition to the in situ formed imines provides N-arylated-α-amino acid derivatives.
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