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Related Experiment Video

Updated: Jun 12, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

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Published on: February 3, 2023

Multi-locus Models of Deleterious Epimutation-Selection Balance and the Evolution of Recombination Modifiers.

Gregory Chernomas¹, Cortland K Griswold¹

¹Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada, N1G 2W1.

G3 (Bethesda, Md.)

|June 11, 2026

Summary

This study explores the balance between deleterious epimutation and transposition. Results suggest reduced recombination evolves, but increased recombination is possible under certain conditions, impacting evolutionary dynamics.

Keywords:

Epigenetics epialleles recombination selfing transposons

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Area of Science:

Evolutionary biology
Genetics
Molecular biology

Background:

Epigenetic inheritance contributes to phenotypic variation.
Epialleles near transposons can be deleterious, similar to genetic mutations.
Transposon activity and epigenetic modifications present a 'double-edged sword' effect.

Purpose of the Study:

To theoretically investigate the balance between deleterious epimutation and transposition.
To analyze the impact of multi-locus interactions on epimutation and transposition dynamics.
To understand how recombination rates are affected by epimutation-transposition balance.

Main Methods:

Development of a multi-locus theoretical model.
Analytical and numerical analysis of epimutation-transposition balance.
Investigation of factors influencing recombination rates.

Main Results:

The balance between transposition and epimutation can lead to the evolution of reduced recombination.
Increased recombination may evolve under conditions of high epiallele reversion rates (e.g., in mammals).
Mating systems, particularly selfing, can critically interact with deleterious transposition-epimutation effects.

Conclusions:

Epigenetic inheritance and transposon activity interact to shape genome evolution.
Recombination rates are dynamically influenced by the interplay of epimutation and transposition.
Understanding these balances is crucial for comprehending phenotypic variation and evolutionary trajectories.