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Impaired kidney function in People with HIV compared to People without HIV.

Gabriela Szereda1, Natalia Alencar de Pinho2, Sylvie Orr1

  • 1Paris-Saclay University, Inserm CESP U1018, Le Kremlin-Bicêtre.

AIDS (London, England)
|June 11, 2026
PubMed
Summary

People with HIV (PWH) have lower kidney function than HIV-negative individuals, even after adjusting for various factors. Regular kidney function monitoring is crucial for PWH to prevent impaired kidney function.

Keywords:
HIVchronicgenderglomerular filtration ratenephrotoxic medicationspopulation-based cohortrenal insufficiency

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Published on: October 6, 2016

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Epidemiology

Background:

  • Impaired kidney function is more prevalent in people with HIV (PWH) than the general population.
  • Understanding kidney function differences requires accounting for socioeconomic, lifestyle, and drug-related factors.

Purpose of the Study:

  • To quantify estimated glomerular filtration rate (eGFR) differences between PWH and HIV-negative individuals.
  • To analyze the impact of socioeconomic status, lifestyle, and drug exposure on eGFR in PWH.

Main Methods:

  • Analysis of baseline data from the French CONSTANCES cohort (2012-2021).
  • Matching PWH with HIV-negative individuals (1:4 ratio) using French National Health Data System linkage.
  • Multivariable linear regression models adjusted for sociodemographic, lifestyle, and drug factors.

Main Results:

  • PWH exhibited lower eGFR levels compared to HIV-negative individuals in both sexes, even after full adjustment.
  • Mean eGFR difference was -7.1 mL/min/1.73 m² in men and -4.9 mL/min/1.73 m² in women.
  • Prevalence of impaired kidney function was significantly higher in PWH (5.6%) versus HIV-negative individuals (1.0%).

Conclusions:

  • Living with HIV is independently associated with reduced kidney function.
  • Highlights the necessity for routine kidney function monitoring in PWH.
  • Emphasizes the importance of minimizing nephrotoxic drug use among PWH.