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Related Experiment Video

Updated: Jun 12, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

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Published on: June 6, 2025

Exercise Exerts Antidepressant Effects via Endoplasmic Reticulum Stress Modulation: Molecular Mechanisms and Research

Xin-Yue Zhou1, Yu-Wei Liu1, Cheng-Hao Zhong1

  • 1College of Physical Education, Yangzhou University, Yangzhou 225127, China.

Biology
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

Exercise improves depression by regulating endoplasmic reticulum stress (ERS) and its downstream signals. It inhibits neuronal apoptosis, inflammation, and calcium imbalance, while restoring autophagy, offering a non-drug approach for depression treatment.

Keywords:
depressionendoplasmic reticulum stressmolecular mechanismmovement

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Psychiatry

Background:

  • Endoplasmic reticulum stress (ERS) activation is a key factor in depression development.
  • Exercise is a safe, non-drug intervention effective for improving depression-like behaviors.

Purpose of the Study:

  • To review the role of ERS in depression, focusing on neuronal apoptosis, inflammation, calcium homeostasis, and autophagy.
  • To analyze the molecular mechanisms by which exercise modulates ERS and its downstream pathways to alleviate depression.

Main Methods:

  • Systematic review of existing literature on ERS, depression, and exercise.
  • Analysis of molecular signaling pathways involved in ERS and exercise interventions.

Main Results:

  • Exercise ameliorates depression by regulating ERS-related signaling networks.
  • Exercise inhibits UPR-related apoptosis, microglial pro-inflammatory polarization, and calcium-mitochondrial interactions.
  • Exercise restores autophagy activity, evidenced by changes in LC3-II and Beclin-1 levels.

Conclusions:

  • Exercise exerts antidepressant effects through multi-level regulation of ERS.
  • Understanding these mechanisms provides a theoretical basis for exercise as a depression therapy.
  • Further research is needed on population studies, exercise types, and intensity for clinical application.