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Circadian Transcriptomic Dynamics Identify Transferable Retina-Choroid Expression Patterns in Myopia Development via
Akarapon Watcharapalakorn1, Teera Poyomtip1, Patarakorn Tawonkasiwattanakun1
1Faculty of Optometry, Ramkhamhaeng University, Bangkok 10240, Thailand.
Biology
|June 11, 2026
Summary
Circadian rhythms influence eye growth and myopia. This study identified a specific daily gene expression pattern in the retina and choroid linked to myopia development, offering new insights into its biological mechanisms.
Area of Science:
- Ophthalmology
- Chronobiology
- Genomics
Background:
- Circadian regulation impacts ocular growth, but its role in myopia development is not fully understood.
- Retina and choroid transcriptomic changes during myopia are complex and influenced by time of day.
Purpose of the Study:
- To investigate the role of circadian timing in retina-choroid transcriptomic responses during myopia development.
- To identify a specific gene signature associated with circadian regulation in myopia using machine learning.
Main Methods:
- Reanalyzed RNA-sequencing datasets from chick models of form-deprivation myopia.
- Applied a multistage machine learning framework to identify a biologically relevant circadian window (ZT8/12).
- Validated the identified gene signature through cross-tissue, cross-stage, and external dataset analyses.
Main Results:
- Machine learning models accurately classified a ZT8/12 circadian window in myopia datasets.
- The identified gene signature represents a stable expression state associated with this circadian window.
- Cross-species analysis suggested functional links between chicken and human genes.
Conclusions:
- Circadian timing is a significant factor in retina-choroid biology during myopia development.
- A computational framework was developed to analyze time-associated gene expression patterns in myopia.
- Further functional validation is needed to confirm the role of circadian timing in myopia pathogenesis.
