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Related Experiment Video

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Effects of Desmodium caudatum on Gastrointestinal Hormones and Intestinal Flora in Rats with Gastritis

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Regulation Progresses of Selenium Improving Intestinal and Extra-Intestinal Tissues Health Through Regulating Gut

Yanle Fan¹, Wenjun Zhang¹, Wenjing Zhuang¹

¹College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, China.

|June 11, 2026

Summary

Dietary selenium (Se) influences gut bacteria, promoting beneficial microbes and suppressing pathogens. This Se-gut-microbiota axis supports gut health and protects distant organs like the liver and brain.

Keywords:

Selenium gut-tissue axis intestinal health metabolism microbiota

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Area of Science:

Nutritional Immunology
Microbiome Research
Trace Element Metabolism

Background:

Selenium (Se) is vital for physiological functions, but its systemic coordination mechanisms are unclear.
The gut microbiota is increasingly recognized as a mediator of Se's biological effects, forming the Se-gut-tissue axis.

Purpose of the Study:

To review how dietary Se impacts gut microbial composition and metabolism.
To explore the association between microbial shifts and protective effects in intestinal and extra-intestinal tissues.

Main Methods:

Literature review synthesizing current research on the Se-gut-microbiota axis.
Analysis of Se's bidirectional interactions with gut bacteria.
Examination of microbial remodeling effects on host physiology.

Main Results:

Dietary Se, especially organic forms, enriches beneficial bacteria (e.g., Akkermansia, Lactobacillus) and inhibits pathogens.
Microbial shifts enhance intestinal barrier function, antioxidant/anti-inflammatory responses, and produce bioactive metabolites like SCFAs.
The Se-gut-microbiota axis influences homeostasis in organs including the liver, brain, muscle, kidney, and reproductive system.

Conclusions:

The Se-gut-microbiota axis plays a significant role in maintaining systemic health.
Further research is needed to establish causality, optimize Se dosage, and develop precision interventions.