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Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy

Jingwen Wang1, Hongyi Wu2, Tianqi Wang2

  • 1School of Public Health, Capital Medical University, Beijing 100069, China.

Cells
|June 11, 2026
PubMed

Insights

Cancer treatment resistance is influenced by both tumor and host metabolism. Targeting this host-tumor metabolic network, considering factors like aging and nutrition, is key to improving cancer therapy efficacy and patient outcomes.

Area of Science:

  • Oncology
  • Metabolic Biology
  • Cancer Research

Background:

  • Therapeutic resistance in cancer is a complex challenge.
  • It stems from both intrinsic tumor metabolic plasticity and the host's systemic metabolic state.
  • Host factors significantly influence cancer progression and treatment response.

Purpose of the Study:

  • To present an integrated framework of the host-tumor metabolic network.
  • To examine how host factors (aging, nutrition, stress) remodel metabolism and affect cancer therapy.
  • To explore the bidirectional interplay between host physiology and anticancer therapies.

Main Methods:

  • Review of existing literature on cancer metabolism and host-tumor interactions.
  • Analysis of how aging, nutrition, and psychological stress impact systemic metabolism.
  • Examination of the consequences of anticancer therapies on host metabolic homeostasis.

Main Results:

  • Host physiology creates a permissive environment for tumor metabolic adaptation.
  • Anticancer therapies disrupt host metabolic homeostasis, potentially accelerating aging and cognitive decline.
  • A bidirectional metabolic interplay exists between the host and the tumor.

Conclusions:

  • Overcoming therapeutic resistance requires targeting both tumor metabolism and the host metabolic milieu.
  • A systemic approach is necessary to redefine precision oncology.
  • Integrated strategies addressing host-tumor metabolic interactions are crucial for enhancing cancer treatment efficacy.
Keywords:
cancer therapyhostmetabolism

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