Related Experiment Video
Updated: Jun 12, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
Published on: January 26, 2019
Accelerated Pace of Biological Aging in People With HIV and Insomnia Living in Southeastern United States: A
Khalid W Freij1,2,3,4,5,6,7,8,9,10, Shannon G Wilson1,2,3,4,5,6,7,8,9,10, Dyan M White-Gilliam1,2,3,4,5,6,7,8,9,10
1Khalid W. Freij, PhD, is a Staff Scientist and Bioinformatician, Department of Acute, Chronic, & Continuing Care, School of Nursing, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abstract:
Our study examined the relationship between insomnia and the pace of biological aging in persons with HIV (PWH). We used Dunedin Pace of Aging from the Epigenome (DunedinPACE) to determine pace of biological aging in adults, ages 18 to 85 years: 34 without HIV or insomnia, 13 without HIV but with insomnia, 22 with HIV but no insomnia, and 38 with HIV and insomnia. Findings revealed that irrespective of insomnia status, PWH had a greater acceleration of biological aging (DunedinPACE) compared with those without HIV. PWH with insomnia demonstrated many of the highest values for DunedinPACE. This suggests that sleep disruption may act as an additional mechanism compounding immune aging and chronic inflammation already associated with HIV, such that PWH who also experience insomnia face a cumulative burden of risk factors that together drive a faster pace of biological aging.
Related Concept Videos
Pharmacodynamics in Geriatric Patients: Effects of Age
The Effect of Aging on Tissues
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Management of Insomnia
