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The Role of Serotonergic System in Parkinson's Disease-Related Pain
Yi-Zhi Song1,2, Yan-Qin Shen3,4,5
1Laboratory of Neurodegenerative Disease, Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Abstract:
Pain affects up to 85% of Parkinson's disease (PD) patients, but treatment options remain limited. The brainstem serotonergic raphe nuclei, as the main source of central serotonin, dysfunction early in PD. Serotonin mediates descending pain inhibition to the spinal cord, and disruption of this pathway likely increases pain susceptibility. Concurrently, serotonergic projections to supraspinal regions shape the emotional-affective dimension of pain, which may explain why mood disturbances and pain often co-occur in PD. Clinically, selective serotonin reuptake inhibitors (SSRIs) and other serotonin-targeting drugs show efficacy in both PD depression and chronic pain conditions. This review synthesizes current evidence on serotonergic mechanisms in PD pain and identifies potential therapeutic targets, thereby providing a foundation for mechanism-based treatment strategies.
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