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Related Experiment Videos

Electrostatic Microsphere Intestinal Aging Model and Traditional Chinese Medicine Antiaging Mechanism Study.

Xia Cao1,2, Jin Zhang1,2, Xiaoli Li1,2

  • 1Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, People's Republic of China.

ACS Applied Bio Materials
|June 11, 2026
PubMed
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This summary is machine-generated.

This study developed controllable intestinal organoids for antiaging research. Myricetin, a traditional Chinese medicine component, effectively suppressed intestinal aging by reducing inflammation and inhibiting key signaling pathways.

Area of Science:

  • Biotechnology
  • Gastroenterology
  • Pharmacology

Background:

  • Intestinal organoids are valuable models for studying gut physiology and antiaging mechanisms.
  • Traditional organoid culture methods lack control over size and growth.
  • There is a need for improved models to screen traditional Chinese medicine (TCM) for antiaging compounds.

Purpose of the Study:

  • To develop a controllable method for generating intestinal organoids using electrostatic spraying technology.
  • To establish an intestinal organoid aging model to investigate TCM components.
  • To identify and elucidate the antiaging mechanisms of TCM-derived bioactive compounds.

Main Methods:

  • Induced pluripotent stem cell microspheres were created using electrostatic spraying and differentiated into intestinal organoids.
Keywords:
antiagingherbal active ingredientsintestinal organoidsmicrospheresthree-dimensional culture

Related Experiment Videos

  • An intestinal aging model was established using lipopolysaccharide (LPS) induction.
  • Ten TCM components were screened for antiaging effects, and the mechanisms of promising candidates were analyzed via transcriptomics.

    • Main Results:

    • Electrostatic spraying enabled controllable preparation of intestinal organoids.
    • LPS induction successfully created an intestinal aging model, evidenced by increased aging markers (P16, P21) and proinflammatory cytokines (IL-1β, TNF-α, MCP-1).
    • Myricetin demonstrated significant antiaging effects by inhibiting NF-κB activation, reducing inflammation, and modulating MAPK, PI3K/Akt, and NF-κB signaling pathways.

    Conclusions:

    • This study presents a novel, controllable method for generating intestinal organoids.
    • The developed model is effective for screening TCM-derived antiaging compounds.
    • Myricetin shows potential as an antiaging agent for intestinal health through specific molecular pathways.