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Related Experiment Video

Updated: Jun 13, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Hippo signalling as a nexus in host-virus interactions.

Aida Bahrami^1,2, Cheryl Walter², Amin Ardestani²

¹Institute‌‌ of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

|June 11, 2026

Summary

The Hippo signalling pathway regulates host-virus interactions, influencing immunity and viral replication. Its components can either support or suppress antiviral defence, depending on the specific context of infection.

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Last Updated: Jun 13, 2026

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Area of Science:

Immunology
Virology
Cell Biology

Background:

The Hippo signalling pathway is crucial in regulating cellular processes.
It plays a significant role in host-virus interactions, affecting immunity and viral replication.
Components like MST1/2, LATS1/2, YAP, and TAZ have context-dependent roles in antiviral responses.

Purpose of the Study:

To review current evidence on Hippo signalling pathway crosstalk with viruses.
To highlight the pathway's role in acute antiviral defence and chronic pathological remodelling.
To discuss therapeutic strategies and challenges related to targeting the Hippo pathway.

Main Methods:

Literature review of recent studies on Hippo signalling and viral infections.
Analysis of context-dependent effects of Hippo pathway components (YAP, TAZ, MST1/2, LATS1/2).
Synthesis of information on immune signalling, viral replication, and tissue repair.

Main Results:

Upstream Hippo kinases (MST1/2, LATS1/2) generally promote antiviral immunity.
YAP and TAZ often suppress innate immunity and can be exploited by viruses.
The pathway's influence is highly context-dependent on viral species, cell type, and infection stage.

Conclusions:

The Hippo pathway is a complex regulator of host-virus interactions with dual roles.
It impacts both antiviral defence and pathological tissue remodelling.
Targeting the Hippo pathway for therapeutic benefit requires careful consideration due to its multifaceted functions.