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Updated: Jun 13, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Hippo signalling as a nexus in host-virus interactions
Aida Bahrami1,2, Cheryl Walter2, Amin Ardestani2
1Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Plos Pathogens
|June 11, 2026
Summary
The Hippo signalling pathway regulates host-virus interactions, influencing immunity and viral replication. Its components can either support or suppress antiviral defence, depending on the specific context of infection.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- The Hippo signalling pathway is crucial in regulating cellular processes.
- It plays a significant role in host-virus interactions, affecting immunity and viral replication.
- Components like MST1/2, LATS1/2, YAP, and TAZ have context-dependent roles in antiviral responses.
Purpose of the Study:
- To review current evidence on Hippo signalling pathway crosstalk with viruses.
- To highlight the pathway's role in acute antiviral defence and chronic pathological remodelling.
- To discuss therapeutic strategies and challenges related to targeting the Hippo pathway.
Main Methods:
- Literature review of recent studies on Hippo signalling and viral infections.
- Analysis of context-dependent effects of Hippo pathway components (YAP, TAZ, MST1/2, LATS1/2).
- Synthesis of information on immune signalling, viral replication, and tissue repair.
Main Results:
- Upstream Hippo kinases (MST1/2, LATS1/2) generally promote antiviral immunity.
- YAP and TAZ often suppress innate immunity and can be exploited by viruses.
- The pathway's influence is highly context-dependent on viral species, cell type, and infection stage.
Conclusions:
- The Hippo pathway is a complex regulator of host-virus interactions with dual roles.
- It impacts both antiviral defence and pathological tissue remodelling.
- Targeting the Hippo pathway for therapeutic benefit requires careful consideration due to its multifaceted functions.
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