Related Experiment Video
Updated: Jun 13, 2026

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
Published on: November 1, 2024
In (qualified) defense of the research project grant
1Pierre Azoulay is the International Programs Professor of Management at the Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA, USA and a research associate at the National Bureau of Economic Research, Cambridge, MA, USA.
Abstract:
In a debate that has been building for years, a growing coalition of reformers has concluded that the research project grant (RPG) approach used by many science funders in the United States and based on competitive, investigator-initiated, and peer-reviewed proposals cannot support transformative science. Crystallizing this debate, the US National Science Foundation (NSF) has just committed $1.5 billion over the next decade to X-Labs, independent and milestone-driven research organizations meant to bypass not only the RPG but also the universities that have long been its principal recipients. Although the reform impulse may warrant sympathy, the X-Labs prescription merits skepticism.
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