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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 13, 2026

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
09:02

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Published on: September 27, 2024

Advances in Quinazolinone-Based Tumor-Targeted Inhibitors.

Jieming Li1,2, Shuaiyi Lv1,2, Bin Yang3

  • 1Henan University of Chinese Medicine, Zhengzhou, China.

Chemistry & Biodiversity
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

Quinazolinone derivatives show promise as targeted antitumor agents by inhibiting key cancer pathways like tyrosine kinases (EGFR, VEGFR). Novel compounds offer dual-target synergy to combat tumor heterogeneity and drug resistance.

Keywords:
antitumor mechanismsmolecular targetspharmacological activitiesquinazolinone derivativesstructure–activity relationship

Related Experiment Videos

Last Updated: Jun 13, 2026

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
09:02

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Published on: September 27, 2024

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Oncology

Background:

  • Quinazolinone derivatives possess a versatile scaffold for developing targeted antitumor agents.
  • Their structural tunability allows for optimization of pharmacological properties.

Purpose of the Study:

  • To systematically review recent advancements in the antitumor pharmacology of quinazolinone derivatives.
  • To summarize their multifaceted mechanisms of action and target inhibitor development.

Main Methods:

  • Literature review of preclinical and clinical studies on quinazolinone derivatives.
  • Analysis of structure-activity relationships (SAR) for optimized drug design.

Main Results:

  • Quinazolinones effectively inhibit tyrosine kinases (e.g., EGFR, VEGFR), PI3K/AKT/mTOR signaling, and epigenetic regulators.
  • These mechanisms block tumor proliferation, induce apoptosis, and reduce angiogenesis and metabolic reprogramming.
  • Novel derivatives demonstrate dual-target synergy, overcoming resistance and addressing tumor heterogeneity.

Conclusions:

  • Quinazolinone derivatives represent a promising class of targeted antitumor agents with diverse mechanisms.
  • SAR studies and dual-target strategies are crucial for developing effective cancer therapies.