Related Experiment Video
Updated: Jun 13, 2026

14:37
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
Published on: November 1, 2017
RUNX1+23 Enhancer Marks Erythro-Megakaryocyte Lineages in Early Waves of Hematopoiesis in Human ESC Differentiation
Chika Nishida1, Michihiro Kopbayashi2, Alina Syed1
1University of Texas Health Science Center at Houston, Houston, Texas, United States.
Blood Advances
|June 11, 2026
Abstract
No abstract available in PubMed .
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Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Lineage Commitment
Commitment is the process whereby stem cells:
Production of Formed Elements
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...

