Related Experiment Video

Updated: Jun 13, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Post-translational regulation of steroidogenesis and its clinical relevance in hormone responsive cancers

Roopika Sankar1, Ganesh Venkatraman1

  • 1Department of Bio-Medical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

Seminars in Oncology
|June 11, 2026
PubMed

Insights

This study details key enzymes in hormone synthesis, revealing how their regulation impacts hormone-related cancers. Understanding these steroidogenic pathways offers new targets for cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Hormone-related cancers are a major global health issue with high mortality.
  • Steroidogenesis, the hormone synthesis pathway, is crucial in cancer development and progression.
  • Enzyme dysregulation and post-translational modifications significantly influence cancer cell behavior.

Purpose of the Study:

  • To comprehensively analyze the function and regulation of key steroidogenic enzymes and StAR.
  • To integrate information on expression, domains, post-translational modifications, and involved kinases.
  • To identify novel therapeutic targets for hormone-related cancers.

Main Methods:

  • Bioinformatic analysis of steroidogenic enzymes (Desmolase, 17α-hydroxylase, 3β-HSD, 17β-HSD) and StAR.
  • Examination of enzyme expression patterns and domain architectures.
  • Compilation of known post-translational modification sites and associated kinases.

Main Results:

  • Detailed functional and regulatory insights into four key steroidogenic enzymes and StAR.
  • Integrated overview of expression, structure, and post-translational modifications.
  • Identification of specific kinases modulating enzyme activity and stability.

Conclusions:

  • Elucidation of molecular details provides a foundation for understanding enzyme roles in cancer.
  • Disruptions in steroidogenesis and enzyme regulation are critical in hormone-related cancers.
  • This research opens new avenues for targeted therapeutic strategies in oncology.
Keywords:
Domain configurationEnzyme regulationHormone-related cancerPost-translational modificationSteroidogenesis

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