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Updated: Jun 13, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
STING unlocks CD4⁺ T cell immunity in pancreatic cancer
Bastian Kruse1, Ben P Leonhardt1, Jan P Böttcher2
1Department of Experimental Immunology, Institute of Immunology, Eberhard Karls University of Tübingen, Tübingen, Germany; M3 Research Center, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany.
None:
Pancreatic ductal adenocarcinomas (PDACs) are lethal cancers resistant to immunotherapies. In this issue of Cancer Cell, Kureshi et al. show that combining checkpoint blockade with STING-mediated innate immune stimulation unlocks cDC2-driven CD4+ T cell immunity in mice, promoting PDAC immune control. This cellular axis may be exploited for PDAC therapy.
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