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Updated: Jun 13, 2026
Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice
Published on: August 10, 2019
A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.
Patrick Jendritza1, Rickard Liljemalm2, Thomas Stieglitz3
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, Germany; International Max Planck Research School for Neural Circuits, Max-von-Laue-Straße 4, 60438 Frankfurt, Germany; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center Göttingen, Göttingen, Germany; Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany; Visual Circuits & Interfaces group, German Primate Center, Göttingen, Germany.
New hybrid micro-electrocorticography (μECoG) arrays enable simultaneous recording of brain activity across multiple scales. This technology bridges local neural dynamics with global brain networks for advanced systems neuroscience research.
Area of Science:
- Systems Neuroscience
- Neurotechnology
- Electrophysiology
Background:
- Brain function integrates activity across diverse spatial and temporal scales.
- Understanding integrated brain function necessitates tools for recording from distributed, connected neural populations.
- Bridging local neuronal activity with global brain dynamics is crucial for systems neuroscience.
Purpose of the Study:
- To introduce high-density, hybrid micro-electrocorticography (μECoG) arrays for multi-scale brain activity studies.
- To demonstrate the utility of these arrays in functional mapping and multi-area laminar recordings.
- To showcase their application in investigating cortico-cortical interactions via optogenetic stimulation.
Main Methods:
- Development of hybrid μECoG arrays combining silicone elastomers and polyimide films.
- Utilizing arrays for high-throughput functional mapping in rodents and non-human primates.
- Performing multi-area laminar recordings guided by functional maps.
- Implementing local and feedforward optogenetic stimulation for studying neural interactions.
Main Results:
- Demonstrated successful functional mapping in rats, cats, and marmosets.
- Showcased how functional maps guide precise insertion of intracortical arrays for dense local sampling.
- Validated the arrays' capability for multi-area laminar recordings.
- Confirmed the utility of hybrid μECoG arrays for investigating cortico-cortical interactions.
Conclusions:
- Hybrid μECoG arrays offer a powerful tool for multi-scale brain activity recording.
- This technology facilitates bridging local and global brain dynamics.
- The developed arrays represent a significant advancement for systems neuroscience research.
