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Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
FGFR3-Altered Urothelial Carcinoma: Clinicopathologic Observations With Emphasis on Variant Histology
Katrina Collins1, Liang Cheng2
1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Summary
FGFR3 alterations are common in urothelial carcinoma, particularly S249C and Y373C mutations, and are linked to variant histology like micropapillary and squamous differentiation.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- Urothelial carcinoma is a significant health concern.
- Understanding genetic alterations is crucial for targeted therapies.
Purpose of the Study:
- To determine the frequency and spectrum of FGFR3 alterations in urothelial carcinoma.
- To evaluate the association between FGFR3 alterations and histologic variants.
Main Methods:
- Analysis of 190 urothelial carcinoma cases.
- Detection of FGFR3 alterations, including mutations and fusions.
Main Results:
- FGFR3 alterations were found in 17% of patients (33/190).
- S249C and Y373C were the most common mutations.
- Variant histology (micropapillary, squamous) was present in 76% of tumors with FGFR3 alterations and exclusively harbored S249C or Y373C mutations.
Conclusions:
- Hotspot FGFR3 alterations (S249C, Y373C) are consistently associated with specific variant histologies in urothelial carcinoma.
- Recognition of these variant histologies may guide targeted FGFR testing.
