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Related Experiment Video

Updated: Jun 13, 2026

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals
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A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals

Published on: June 25, 2018

In vitro exposure to polystyrene microplastic induces oxidative stress mediated β-cell dysfunction.

Pratibha Verma1, Fariya Khan1, Vinod Verma1

  • 1Stem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|June 11, 2026
PubMed
Summary

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This summary is machine-generated.

Polystyrene microplastics (PS-MPs) exposure harms pancreatic beta cells, causing oxidative stress, cell death, and dysfunction. This suggests microplastics may contribute to diabetes development.

Area of Science:

  • Environmental Science
  • Toxicology
  • Endocrinology

Background:

  • Microplastics (MPs) are widespread environmental pollutants found in human tissues.
  • Polystyrene microplastics (PS-MPs) are frequently detected in metabolically active organs.
  • Concerns exist regarding the role of PS-MPs in diabetes development.

Purpose of the Study:

  • To investigate the cellular and functional effects of PS-MP exposure on pancreatic beta cells.
  • To determine the impact of PS-MPs on beta cell viability, oxidative stress, and function.

Main Methods:

  • Utilized the MIN6 cell line to model pancreatic beta cells.
  • Exposed cells to 1 μm PS-MPs.
  • Assessed PS-MP internalization, localization, reactive oxygen species (ROS) production, mitochondrial superoxide levels, cell viability, and expression of beta cell markers (PDX1, MAFA).
Keywords:
DiabetesEnvironmental toxicityOxidative stressPolystyrene microplastics (PS-MPs), pancreatic β-cells

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Last Updated: Jun 13, 2026

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Published on: June 25, 2018

Sustained Administration of &#946;-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

Main Results:

  • PS-MPs were internalized and localized in pancreatic beta cells.
  • PS-MP exposure increased oxidative stress (superoxide and ROS) in a dose- and time-dependent manner.
  • Significant suppression of beta cell function markers, reduced viability, and increased necrotic cell death were observed.
  • PDX1 and MAFA expression was suppressed, indicating impaired beta cell identity.

Conclusions:

  • PS-MP exposure induces oxidative stress, cytotoxicity, and necrosis in pancreatic beta cells.
  • These effects lead to early beta cell dysfunction and impaired insulin production.
  • Findings suggest a link between microplastic exposure and increased susceptibility to diabetes, identifying MPs as potential metabolic disruptors.