Related Experiment Video
Updated: Jun 13, 2026

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Prevalence and risk outcomes of overheating, fire and explosion incidents related to electronic nicotine delivery
Erik Crankshaw1, Matthew E Eggers2, Azieb Kidanu3
1RTI International, Durham, North Carolina, USA ecrankshaw@rti.org.
Background:
Studies have documented overheating, fire and explosion (OFE) incidents related to the use of lithium-ion batteries in electronic nicotine delivery systems (ENDS). These incidents can lead to property damage, injuries and even death. Most incidents are not reported to the US Food and Drug Administration, and those that are reported frequently lack sufficient information to convey the acute risks and pinpoint mitigation strategies.
Methods:
A convenience sample of 6010 adults who used ENDS completed a self-administered online survey about their ENDS device and battery, use behaviours and any experience of OFE incidents. The data were calibrated to estimate population-level statistics for US adults who use ENDS.
Results:
Approximately half the respondents reported experiencing an OFE incident. About one-third reported having experienced a serious OFE incident (ie, overheating that caused visible damage to the device/battery, other property damage or burns; fire; explosion). A total of 4.8% of respondents who used ENDS reported that they or someone else had experienced an injury because of a serious OFE incident, and 1.1% reported that medical care was required.
Conclusions:
Given the prevalence of OFE incidents and potential risk factors, our findings suggest incidents are underreported and reporting systems could capture them in greater detail. Complete information on the device characteristics, use behaviours and outcomes associated with incidents may inform preventive actions by individuals, public education and regulatory activities.
More Related Videos
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
10:44Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Related Concept Videos
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Drug Toxicity: Risk factors
Pharmaceutical Poisoning: Potential Scenarios
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...