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Pancreas

Pancreas

The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short and...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

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OPTN/SRTR 2024 Annual Data Report: Pancreas.

Raja Kandaswamy¹, Peter G Stock², Jonathan M Miller³

¹Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Surgery, University of Minnesota, Minneapolis, MN.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|June 11, 2026

Summary

Pancreas transplants declined in 2024, with fewer simultaneous pancreas-kidney (SPK) transplants despite increased waitlist additions. However, patient outcomes remain strong, showing low graft loss and improved long-term survival rates post-transplant.

Keywords:

Pancreas transplant transplant outcomes waitlist outcomes

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Area of Science:

Transplantation Medicine
Nephrology
Endocrinology

Background:

The number of adult pancreas transplants in the US decreased by 8.0% in 2024, largely due to a decline in simultaneous pancreas-kidney (SPK) transplants.
Despite the overall decrease in transplants, adult waitlist additions for SPK transplants rose in 2024.
Adult pancreas transplant rates have been on a steady decline since 2019, reaching a low of 30.1 per 100 patient-years in 2024.

Purpose of the Study:

To analyze trends in adult pancreas transplantation in the United States for 2024.
To assess changes in waitlist dynamics, donor characteristics, and transplant outcomes.
To evaluate the success rates of various pancreas transplant procedures, including SPK.

Main Methods:

Analysis of national transplant data for adult pancreas transplants in 2024.
Comparison of 2024 data with previous years to identify trends in transplant numbers, waitlist additions, and donor counts.
Evaluation of graft survival and patient mortality rates following different types of pancreas transplants.

Main Results:

Overall adult pancreas transplants dropped to 821 in 2024, with SPK transplants showing a significant decline.
Adult SPK waitlist additions increased, while transplant rates continued to fall.
Pancreas donor counts decreased, and 25.1% of recovered pancreata were not transplanted.
Post-transplant outcomes remained robust, with low first-year graft loss (9.4% for SPK) and improved long-term survival rates.

Conclusions:

Despite a decrease in overall pancreas transplants and donor availability, outcomes for adult pancreas transplant recipients, particularly SPK, remain strong.
The declining transplant rates and increasing waitlist additions highlight a growing gap in organ availability for patients needing pancreas transplants.
Further research and strategies are needed to address the decline in donor numbers and improve access to life-saving pancreas transplants.