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OPTN/SRTR 2024 Annual Data Report: Pancreas.
Raja Kandaswamy1, Peter G Stock2, Jonathan M Miller3
1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Surgery, University of Minnesota, Minneapolis, MN.
Summary
Pancreas transplants declined in 2024, with fewer simultaneous pancreas-kidney (SPK) transplants despite increased waitlist additions. However, patient outcomes remain strong, showing low graft loss and improved long-term survival rates post-transplant.
Area of Science:
- Transplantation Medicine
- Nephrology
- Endocrinology
Background:
- The number of adult pancreas transplants in the US decreased by 8.0% in 2024, largely due to a decline in simultaneous pancreas-kidney (SPK) transplants.
- Despite the overall decrease in transplants, adult waitlist additions for SPK transplants rose in 2024.
- Adult pancreas transplant rates have been on a steady decline since 2019, reaching a low of 30.1 per 100 patient-years in 2024.
Purpose of the Study:
- To analyze trends in adult pancreas transplantation in the United States for 2024.
- To assess changes in waitlist dynamics, donor characteristics, and transplant outcomes.
- To evaluate the success rates of various pancreas transplant procedures, including SPK.
Main Methods:
- Analysis of national transplant data for adult pancreas transplants in 2024.
- Comparison of 2024 data with previous years to identify trends in transplant numbers, waitlist additions, and donor counts.
- Evaluation of graft survival and patient mortality rates following different types of pancreas transplants.
Main Results:
- Overall adult pancreas transplants dropped to 821 in 2024, with SPK transplants showing a significant decline.
- Adult SPK waitlist additions increased, while transplant rates continued to fall.
- Pancreas donor counts decreased, and 25.1% of recovered pancreata were not transplanted.
- Post-transplant outcomes remained robust, with low first-year graft loss (9.4% for SPK) and improved long-term survival rates.
Conclusions:
- Despite a decrease in overall pancreas transplants and donor availability, outcomes for adult pancreas transplant recipients, particularly SPK, remain strong.
- The declining transplant rates and increasing waitlist additions highlight a growing gap in organ availability for patients needing pancreas transplants.
- Further research and strategies are needed to address the decline in donor numbers and improve access to life-saving pancreas transplants.
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