Advances in the Use of Cell-Based Therapies for Prevention of Bronchopulmonary Dysplasia
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Updated: Jun 13, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
Published on: May 4, 2020
So Yoon Ahn1, Andreas Damianos2, Kevin Williams3
1Department of Pediatrics, Samsung Medical Centre Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea; Stem Cell and Regenerative Medicine Institute, Samsung Medical Centre, Seoul, South Korea.
Abstract:
Bronchopulmonary dysplasia (BPD) is a multifactorial disease characterized by disordered angiogenesis and disrupted alveolar development. Stem cell-based therapies, including extracellular vesicles, offer a transformative approach for BPD prevention and treatment. In preclinical studies, cell-based therapies promote lung repair, modulate immune responses, and replenish endogenous progenitor cells. This article critically evaluates the therapeutic potential of stem cell interventions for BPD, while also examining key barriers to clinical translation, including challenges in manufacturing, regulatory oversight, and standardization of cell-based products.
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