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Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A
Chunyan Deng1,2, Wei Sun3, Tianhu Gao1
1Department of Radiology, Banan Hospital, Chongqing Medical University, Chongqing, China.
Journal of Magnetic Resonance Imaging : JMRI
|June 11, 2026
Summary
Cardiac MRI markers like extracellular volume (ECV) and native T1 can predict early HIV infection. A multimodal model including LV end-diastolic volume (LVEDVi) and extracellular matrix volume index (ECMVi) stratifies disease duration.
Area of Science:
- Cardiovascular Imaging
- Infectious Diseases
- Biomarkers
Background:
- Antiretroviral therapy has chronicled HIV, but cardiac injury persists.
- Cardiac complications remain a significant concern in HIV management.
Purpose of the Study:
- To evaluate cardiac MRI markers for predicting cardiac injury in HIV.
- To assess MRI's ability to predict HIV disease progression.
Main Methods:
- Prospective study of 83 HIV-infected individuals and 34 controls.
- Utilized 1.5T MRI with SSFP cine and MOLLI sequences.
- Assessed LV volumes, ejection fraction, mass, strains, ECV, and ECMVi.
Main Results:
- HIV groups showed elevated ECV and native T1 compared to controls.
- Long-duration HIV group had higher ECMVi, MVR, and reduced LVEDVi and global radial strain.
- MRI models including ECV, native T1, LVEDVi, ECMVi, and fasting blood glucose (FBG) predicted early HIV and stratified duration.
Conclusions:
- ECV, native T1, and FBG predict short-duration HIV infection.
- A multimodal MRI model (LVEDVi, ECMVi, FBG) stratifies HIV duration.
- Prospective validation of these findings is recommended.
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