Related Experiment Video

Updated: Jun 13, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Prognostic Value of MRI-Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic

Jinquan Zhang1, Mengdi Yu1, Lutong Pu1

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Journal of Magnetic Resonance Imaging : JMRI
|June 11, 2026
PubMed

Insights

Left ventricular fractal dimension (FD) predicts sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) patients. Elevated FD, particularly in the apex, indicates higher risk and correlates with MYBPC3 genetic variants.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary cause of sudden cardiac death (SCD).
  • Accurate risk stratification is crucial for timely intervention in HCM patients.

Purpose of the Study:

  • To validate left ventricular (LV) myocardial trabecular complexity using fractal dimension (FD) for SCD prediction.
  • To investigate the association between LV FD and sarcomere variants in a large HCM cohort.

Main Methods:

  • Prospective study of 835 HCM patients using 3T cardiac MRI with SSFP cine sequences.
  • Independent analysis of LV global and apical FD by two blinded cardiologists.
  • Cox regression and Kaplan-Meier analyses for SCD prediction; Welch's t-test for genetic variant comparisons.

Main Results:

  • Global and apical LV FD independently predicted SCD, improving risk stratification models.
  • Higher FD values were observed in MYBPC3 variant carriers compared to other sarcomere variant carriers.
  • LV FD measurements demonstrated incremental prognostic value beyond established risk predictors.

Conclusions:

  • LV global and apical FD are valuable independent predictors of SCD in HCM.
  • Trabecular complexity, quantified by FD, is linked to specific genetic variants like MYBPC3.
  • FD analysis offers a novel approach for risk assessment in HCM.
Abstract

Keywords:
MYBPC3fractal analysishypertrophic cardiomyopathymagnetic resonance imagingsudden cardiac death

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