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Visible-Light-Mediated Three-Component Synthesis of Perfluoroalkylated Quinoline Derivatives via an Electron
Dan-Dan Li1, Zhuo-Ying Dong1, Qian-Qian Fan1
1School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, PR China.
Abstract:
Herein, we report a novel visible-light-mediated electron donor-acceptor (EDA) complex-promoted three-component perfluoroalkylation/cyclization strategy. Enaminones, perfluoroalkanes, and anilines underwent direct cyclization in the presence of DABCO under visible-light irradiation, efficiently constructing perfluoroalkyl-substituted quinoline derivatives. The key innovation of this transformation lies in the utilization of an EDA complex formed between perfluoroalkanes and an organic base to drive the reaction, delivering the target products in good to excellent yields. This protocol provides a new pathway for the efficient construction of perfluoroalkyl-substituted quinoline scaffolds, which holds significant potential in medicinal chemistry and materials science.
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