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Updated: Jun 13, 2026

Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 23, 2013
Chlamydia trachomatis orchestrates multifaceted host cell manipulation for immune evasion
Deepthi Krishnan Nair Geetha1, Paridhi Agarwal1,2, Athulya Thiruvacholayil1,2
1Infection Biology Laboratory, Pathogen Biology Department, BRIC-Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India.
Abstract:
Chlamydia trachomatis is an obligate intracellular sexually transmitted human pathogen and a major cause of ocular and urogenital infections worldwide, causing significant reproductive and neonatal complications. Despite eliciting host immune responses, C. trachomatis infections frequently remain asymptomatic, contributing to silent epidemic that often progress to chronic disease. This paradox reflects the remarkable ability of the pathogen to intricately manipulate host cell survival pathways and immune signalling networks. This review synthesizes current knowledge of C. trachomatis pathogenesis and host-pathogen interactions, with a particular emphasis on immune evasion strategies, the implications of which might be effective for therapeutic and preventive approaches.
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