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Improving cancer care while reducing its carbon footprint: GHG-mitigating strategies highlighted at ESMO 2025
Matthieu Delaye1, Paul Matte2, Anthony Turpin3
1Institut Curie, Department of Medical Oncology, Versailles Saint-Quentin University, Saint-Cloud, France. matthieu.delaye@curie.fr.
Background:
The environmental impact of cancer care is an emerging concern, yet therapeutic strategies that may incidentally reduce greenhouse gas (GHG) emissions remain poorly described. The 2025 ESMO Congress, where nearly 3000 abstracts were presented, offered an opportunity to identify clinically validated approaches that could lower the carbon footprint of oncology.
Methods:
All abstracts from the 2025 ESMO Congress were reviewed. Studies suggesting meaningful downstream reductions in drug use, visit frequency, treatment duration, or overall care intensity were selected. For each, GHG emissions were estimated using the ECOVAMED drug carbon-footprint database and standard emission factors.
Results:
Ten abstracts were identified. They spanned primary prevention, therapeutic de-escalation, reduced dose or duration of systemic therapy, biomarker-guided treatment selection, and non-pharmacological interventions. Several strategies demonstrated non-inferior or improved clinical outcomes while substantially lowering treatment-related emissions. Notably, none of the selected studies had explicitly assessed environmental impact.
Conclusions:
Multiple strategies presented at ESMO 2025 appear capable of improving patient outcomes while reducing the environmental burden of cancer care. Systematically integrating environmental endpoints into clinical research would help identify such win-win approaches and advance a more sustainable oncology practice.
Insights
Cancer care strategies can significantly lower greenhouse gas (GHG) emissions. Research presented at ESMO 2025 showed improved patient outcomes alongside reduced environmental impact from oncology treatments.
Area of Science:
- Oncology
- Environmental Science
- Public Health
Background:
- The environmental impact of cancer care, including greenhouse gas (GHG) emissions, is a growing concern.
- Limited data exists on therapeutic strategies that incidentally reduce the carbon footprint of oncology.
Purpose of the Study:
- To identify clinically validated approaches presented at the 2025 ESMO Congress that could lower the carbon footprint of cancer care.
- To assess strategies for reducing drug use, visit frequency, treatment duration, and overall care intensity.
Main Methods:
- Review of all abstracts from the 2025 ESMO Congress.
- Selection of studies indicating potential reductions in resource utilization.
- Estimation of GHG emissions using the ECOVAMED drug carbon-footprint database and standard emission factors.
Main Results:
- Ten abstracts were identified, covering primary prevention, de-escalation, dose/duration reduction, biomarker-guided therapy, and non-pharmacological interventions.
- Several strategies showed non-inferior or improved clinical outcomes with substantial reductions in treatment-related emissions.
- None of the selected studies explicitly assessed the environmental impact.
Conclusions:
- Multiple strategies presented at ESMO 2025 demonstrate potential for improving patient outcomes while reducing the environmental burden of cancer care.
- Systematic integration of environmental endpoints into clinical research is crucial for advancing sustainable oncology practices.
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