Related Experiment Video
Updated: Jun 13, 2026
07:46
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 15, 2010
Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis
Mostafa Norouzzadeh1,2, Minoo Hasan Rashedi3,4, Ghazaleh Mahdavi-Mazdeh3,4
1Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Current Atherosclerosis Reports
|June 11, 2026
Summary
Dietary magnesium and vitamin D3 significantly improve endothelial function, measured by flow-mediated dilation (FMD), in individuals with cardiovascular diseases and hypertension. These findings support nutritional strategies for vascular health.
Area of Science:
- Cardiovascular Research
- Nutritional Science
- Endothelial Function
Background:
- Endothelial dysfunction is a key factor in cardiovascular diseases (CVDs) and hypertension.
- Dietary interventions are being explored as adjunct therapies for vascular health.
Purpose of the Study:
- To compare the efficacy of various dietary interventions in improving flow-mediated dilation (FMD) in individuals with CVDs and hypertension.
- To provide a basis for future clinical trials and evidence-based nutritional guidelines.
Main Methods:
- Network meta-analysis (NMA) comparing dietary interventions for FMD improvement.
- Systematic review registered with PROSPERO (CRD420251041093).
Main Results:
- Magnesium (MD: 8.17) and vitamin D3 (MD: 7.84) showed the most substantial improvements in FMD.
- Flaxseed (MD: 7.39) and barberry (MD: 6.64) also demonstrated significant FMD improvements.
- Sensitivity analyses confirmed the robustness of the findings.
Conclusions:
- Dietary magnesium and vitamin D3 are effective in improving endothelial function in individuals with CVDs and hypertension.
- Nutritional strategies show potential as adjunct therapies for preserving vascular health.
Keywords:
Coronary DiseaseDietary SupplementsHeart FailureMyocardial InfarctionPreventive MedicineVascular DiseasesMore Related Videos
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