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Related Experiment Video

Updated: Jun 13, 2026

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
10:00

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

Published on: December 11, 2020

Rutin Alleviates Oxidative Stress in Chicken Hepatocytes by Inhibiting Ribotoxic Stress Response.

Cangning Zhang1,2, Tao Li1,2, Chengfeng Zhao1,2

  • 1Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China.

Animals : an Open Access Journal From MDPI
|June 12, 2026
PubMed
Summary

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This summary is machine-generated.

Rutin protects chicken liver cells from oxidative stress and reduces fat buildup by targeting the ZAKα signaling pathway. This mechanism enhances antioxidant defenses and lipid metabolism, offering potential for poultry health applications.

Area of Science:

  • Biochemistry
  • Animal Science
  • Cell Biology

Background:

  • Oxidative stress (OS) negatively impacts poultry production.
  • The protective role of rutin against OS in chicken liver cells is not well understood.
  • Investigating rutin's effects on OS and lipid metabolism is crucial for poultry health.

Purpose of the Study:

  • To elucidate the protective mechanisms of rutin against oxidative stress in chicken liver cells.
  • To investigate rutin's impact on lipid metabolism and related signaling pathways.
  • To identify the specific molecular targets and pathways involved in rutin's action.

Main Methods:

  • Primary chicken embryo hepatocytes were exposed to hydrogen peroxide (H₂O₂).
  • Rutin's effects on antioxidant indicators (SOD, T-AOC, MDA, ROS) were assessed.
Keywords:
liveroxidative stresspoultryribotoxic stress responserutin

Related Experiment Videos

Last Updated: Jun 13, 2026

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
10:00

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

Published on: December 11, 2020

  • The Nrf2/Keap1 pathway, ZAKα-mediated ribotoxic stress response (RSR), and lipid metabolism markers (TG, T-CHO, LDL-C, SREBP1) were analyzed.
  • Molecular docking was used to predict the binding affinity between rutin and ZAKα.

    • Main Results:

    • Rutin pretreatment significantly reduced oxidative damage and lipid accumulation.
    • Rutin activated the Nrf2/Keap1 pathway, increasing antioxidant enzyme expression (HO-1, SOD2).
    • Rutin inhibited the ZAKα-p38/JNK pathway, suggesting ZAKα as a key target.
    • ZAKα overexpression diminished rutin's protective effects, confirming the mechanism.

    Conclusions:

    • Rutin exerts protective effects against oxidative stress and lipid deposition in chicken liver cells.
    • The mechanism involves the inhibition of ZAKα-mediated signaling, leading to Nrf2 activation.
    • Rutin shows potential as a therapeutic agent for improving poultry health and production by modulating oxidative stress and lipid metabolism.