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Overview of Exosomes

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Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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Published on: January 26, 2024

Circulating Extracellular Vesicles Suggest Race-Associated Transcriptomic Differences in Preterm Birth: A Pilot

Bruna Corradetti1,2, Xiyu Ge1, Kristina W Whitworth1,3

  • 1Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Extracellular vesicles (EVs) show promise in understanding preterm birth (PTB) disparities. EV concentrations were higher in PTB, with distinct molecular profiles linked to race and gestational outcomes, offering insights into the biological basis of these differences.

Keywords:
extracellular vesiclesplasma transcriptomicspreterm birthracial disparities

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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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Tracking miRNA Release into Extracellular Vesicles using Flow Cytometry
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Tracking miRNA Release into Extracellular Vesicles using Flow Cytometry

Published on: October 6, 2023

Area of Science:

  • Obstetrics and Gynecology
  • Molecular Biology
  • Genomics

Background:

  • Preterm birth (PTB) is a major cause of infant mortality and morbidity.
  • Significant racial disparities exist in PTB rates in the United States, particularly affecting Black women.
  • The molecular mechanisms driving these racial disparities in PTB are not fully understood.

Purpose of the Study:

  • To investigate the role of extracellular vesicles (EVs) in preterm birth (PTB).
  • To explore molecular differences in EVs associated with PTB and race.
  • To identify potential biological pathways contributing to PTB disparities.

Main Methods:

  • Isolation of EVs from maternal plasma at delivery.
  • Profiling of EV-associated mRNA and miRNA cargo using next-generation sequencing.
  • Differential expression and pathway enrichment analyses stratified by gestational outcome and race.

Main Results:

  • EV concentrations were significantly elevated in PTB deliveries, with a greater increase observed in Black participants.
  • A shared mRNA signature enriched for platelet activation and coagulation pathways was identified across racial groups.
  • Distinct EV miRNA profiles were observed in PTB, with race-specific pathway enrichments (cytokine signaling in Black women, apoptosis in White women).

Conclusions:

  • EV profiling offers a novel framework for investigating the biological pathways underlying PTB.
  • EVs may serve as integrative molecular indicators of pregnancy health and stress.
  • Findings highlight distinct molecular mechanisms contributing to PTB disparities by race.