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Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Related Experiment Video

Updated: Jun 13, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

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Published on: June 3, 2016

Adipogenesis Under Leptin Control: Mechanisms and Model-Specific Effects.

Amna Abu Na'aim1, Taty Anna Kamarudin1, Nurul 'Ain Arshad1

  • 1Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary

Leptin, a key adipokine, has a complex and often contradictory role in adipogenesis, the process of fat cell formation. Understanding its context-dependent effects is crucial for metabolic disease research.

Keywords:
adipogenesisadipose tissueleptinleptin signalingpreadipocytes

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Published on: May 4, 2021

Area of Science:

  • * Adipose tissue biology
  • * Metabolic regulation
  • * Cellular differentiation

Background:

  • * Adipogenesis is the process of mesenchymal stem cell (MSC) differentiation into adipocytes, leading to adipose tissue expansion.
  • * Leptin, an adipokine secreted during adipogenesis, is traditionally viewed as a marker of fat mass.
  • * Emerging evidence suggests leptin may actively regulate adipogenesis, but its precise role is debated.

Purpose of the Study:

  • * To review and synthesize current evidence on leptin's influence on adipogenesis.
  • * To explore the molecular mechanisms and signaling pathways involved in leptin's adipogenic effects.
  • * To clarify the context-dependent nature of leptin's role and identify research gaps.

Main Methods:

  • * Comprehensive literature review of studies investigating leptin and adipogenesis.
  • * Integration of findings from diverse experimental models (in vitro and in vivo).
  • * Analysis of molecular mechanisms and signaling pathways.

Main Results:

  • * Leptin exhibits context-dependent effects on adipogenesis, reported as pro-adipogenic, anti-adipogenic, or neutral.
  • * Discrepancies are attributed to variations in leptin concentration, exposure timing, cell type, adipose depot, and species.
  • * Specific molecular pathways influenced by leptin in adipogenesis are examined.

Conclusions:

  • * Leptin's role in adipogenesis is complex and highly dependent on experimental context.
  • * Further research is needed to fully elucidate these context-dependent effects.
  • * Clarifying leptin's regulatory role is essential for understanding adipose tissue biology and metabolic diseases.