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Phase-Dependent MoS2 Nanosheets-Embedded Urinary Catheter for Advanced Photothermal Sterilization
Muhammad Saukani1, Chien-Hung Lai2,3,4,5, Dyah Ika Krisnawati6,7
1Department of Mechanical Engineering, Faculty of Engineering, Universitas Islam Kalimantan MAB, Banjarmasin 70124, Indonesia.
International Journal of Molecular Sciences
|June 12, 2026
Summary
New antibacterial urinary catheters embedded with molybdenum disulfide (MoS2) show effective photothermal sterilization against common bacteria like E. coli and S. aureus. This innovation offers a promising solution for preventing catheter-associated urinary tract infections (CAUTIs).
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Catheter-associated urinary tract infections (CAUTIs) are a significant healthcare challenge.
- Current prevention methods require improvement to reduce infection rates.
- Antibacterial urinary catheters are crucial for clinical settings.
Purpose of the Study:
- To develop novel antibacterial urinary catheters using molybdenum disulfide (MoS2) embedded polydimethylsiloxane (PDMS).
- To investigate the photothermal sterilization capabilities of metallic (1T) and semiconducting (2H) MoS2 phases against bacterial pathogens.
- To evaluate the efficacy of these enhanced catheters in preventing bacterial growth and infection.
Main Methods:
- Synthesis of metallic 1T-MoS2 via hydrothermal method and conversion to semiconducting 2H-MoS2 through annealing.
- Embedding 1T- and 2H-MoS2 nanosheets into PDMS to create antibacterial urinary catheter materials.
- Characterization of MoS2 phases and PDMS composites using optical and structural analysis.
- Assessment of antibacterial efficacy through bacterial growth curves, agar plate tests, and SEM imaging under near-infrared (NIR) laser irradiation.
Main Results:
- Successful synthesis and characterization of 1T- and 2H-MoS2 nanosheets and their incorporation into PDMS.
- Enhanced photothermal conversion efficiency in MoS2-embedded PDMS composites.
- Demonstrated significant inhibition of *E. coli* and *S. aureus* growth with NIR irradiation.
- Complete eradication of *E. coli* and over 99.9% elimination of *S. aureus* achieved in agar plate tests.
Conclusions:
- Phase-dependent MoS2-embedded PDMS urinary catheters exhibit potent photothermal antibacterial properties.
- These catheters effectively damage and eradicate both *E. coli* and *S. aureus* upon NIR laser exposure.
- The developed materials show potential for clinical application as advanced photothermal antibacterial catheters, improving CAUTI prevention.
