Related Experiment Video
Updated: Jun 13, 2026
05:58
Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells
Published on: February 24, 2026
Data Resources and Computational Methods for Lactylation Site Prediction: A Mini-Review.
Cong Wang1, Ye Pan2, Yunlong Wu1
1Data and Informatization Department, Jiangsu University, Zhenjiang 212013, China.
International Journal of Molecular Sciences
|June 12, 2026
Summary
Lysine lactylation (Kla), a new epigenetic regulator, links metabolism to gene expression. This review covers computational tools for predicting Kla sites and its role in diseases like cancer.
Area of Science:
- Biochemistry
- Epigenetics
- Systems Biology
Background:
- Lysine lactylation (Kla) is a recently discovered post-translational modification (PTM) linking cellular metabolism and epigenetic regulation.
- Kla plays significant roles in various physiological and pathological processes, including major human diseases.
Purpose of the Study:
- To review computational methods and data resources for predicting lysine lactylation sites.
- To summarize the biological roles of Kla in diseases such as cancers, cardiovascular diseases, and neurological diseases.
- To provide an overview of existing Kla site prediction models.
Main Methods:
- Literature review of computational prediction models for Kla sites.
- Analysis of dataset construction, methodological principles, and evaluation metrics for prediction models.
- Summary of biological functions and disease associations of Kla.
Main Results:
- Computational models offer efficient alternatives to traditional experimental methods for identifying Kla sites.
- Kla is implicated in the pathogenesis of cancers, cardiovascular diseases, and neurological disorders.
- Seven Kla site prediction models were reviewed, detailing their approaches and performance.
Conclusions:
- Computational prediction of Kla sites is crucial for high-throughput screening and understanding Kla's biological roles.
- Further development of prediction models and exploration of Kla's functions in diseases are warranted.
- This review provides a comprehensive resource for researchers in the field of lysine lactylation.
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