Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidotes01:17

Antidotes

Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health Problems with Mycotoxins in Cattle-A Review.

Molecules (Basel, Switzerland)·2026
Same author

Special Issue: Emerging Topics in Metal Complexes: Pharmacological Activity, 2nd Edition.

International journal of molecular sciences·2025
Same author

The Action of Cannabidiol on Doxycycline Cytotoxicity in Human Cells-In Vitro Study.

Molecules (Basel, Switzerland)·2025
Same author

Special Issue "Medical Value of Metal Complexes and Plant-Derived Compounds: Biological Evaluation, Health Effects, Challenges, and Future Opportunities".

International journal of molecular sciences·2025
Same author

The role of menopausal hormone therapy in hormone-dependent carcinogenic mechanisms in the oral cavity: A literature review.

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2025
Same author

Psychological aspects of plastic surgery: Impact on self-esteem, body image, and quality of life of patients.

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2025

Related Experiment Video

Updated: Jun 13, 2026

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance
08:08

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance

Published on: August 18, 2023

Potential Antidote Against Lead Toxicity-A Review.

Zuzanna Romanowska1, Agnieszka Ścibior2, Lidia Radko3

  • 1Department of Paediatrics, Medical University of Warsaw, Żwirki i Wigury St. 63A, 02-091 Warsaw, Poland.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Certain antioxidants like spirulina, curcumin, garlic, vitamin C, and vitamin E show promise in mitigating lead (Pb) toxicity. Further research is needed to determine safe dosages and long-term effects for effective Pb intoxication treatment.

Keywords:
animalsantioxidantslead toxicityoccupational/environmental lead exposure

More Related Videos

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
09:23

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

Extending the Lifespan of Soluble Lead Flow Batteries with a Sodium Acetate Additive
08:35

Extending the Lifespan of Soluble Lead Flow Batteries with a Sodium Acetate Additive

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jun 13, 2026

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance
08:08

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance

Published on: August 18, 2023

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
09:23

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

Extending the Lifespan of Soluble Lead Flow Batteries with a Sodium Acetate Additive
08:35

Extending the Lifespan of Soluble Lead Flow Batteries with a Sodium Acetate Additive

Published on: January 7, 2019

Area of Science:

  • Environmental Health
  • Toxicology
  • Nutritional Science

Background:

  • Chronic lead (Pb) exposure poses a significant global public health risk.
  • Pb intoxication can lead to severe health complications.
  • Identifying effective antidotes for Pb toxicity is crucial.

Purpose of the Study:

  • To review the efficacy of specific antioxidants as potential antidotes for Pb intoxication.
  • To explore the mechanisms underlying the beneficial actions of these antioxidants.
  • To highlight areas for future research in Pb toxicity management.

Main Methods:

  • Literature review focusing on animal studies.
  • Analysis of recent research on antioxidant supplementation during Pb exposure.
  • Examination of the beneficial mechanisms of antioxidants against Pb toxicity.

Main Results:

  • Spirulina, curcumin, garlic, vitamin C, and vitamin E demonstrated efficacy in alleviating Pb-induced toxic effects in animal models.
  • These antioxidants may play a key role in combating Pb toxicity.
  • Evidence suggests potential therapeutic benefits for Pb intoxication.

Conclusions:

  • Antioxidant supplementation (spirulina, curcumin, garlic, vitamin C, E) shows promise for managing Pb toxicity.
  • Further research, including clinical trials, is essential to establish safe and effective dosages and understand long-term effects.
  • Elucidating molecular mechanisms and interactions with chelating agents is necessary for enhanced therapeutic strategies.