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Potential Antidote Against Lead Toxicity-A Review
Zuzanna Romanowska1, Agnieszka Ścibior2, Lidia Radko3
1Department of Paediatrics, Medical University of Warsaw, Żwirki i Wigury St. 63A, 02-091 Warsaw, Poland.
International Journal of Molecular Sciences
|June 12, 2026
Summary
Certain antioxidants like spirulina, curcumin, garlic, vitamin C, and vitamin E show promise in mitigating lead (Pb) toxicity. Further research is needed to determine safe dosages and long-term effects for effective Pb intoxication treatment.
Area of Science:
- Environmental Health
- Toxicology
- Nutritional Science
Background:
- Chronic lead (Pb) exposure poses a significant global public health risk.
- Pb intoxication can lead to severe health complications.
- Identifying effective antidotes for Pb toxicity is crucial.
Purpose of the Study:
- To review the efficacy of specific antioxidants as potential antidotes for Pb intoxication.
- To explore the mechanisms underlying the beneficial actions of these antioxidants.
- To highlight areas for future research in Pb toxicity management.
Main Methods:
- Literature review focusing on animal studies.
- Analysis of recent research on antioxidant supplementation during Pb exposure.
- Examination of the beneficial mechanisms of antioxidants against Pb toxicity.
Main Results:
- Spirulina, curcumin, garlic, vitamin C, and vitamin E demonstrated efficacy in alleviating Pb-induced toxic effects in animal models.
- These antioxidants may play a key role in combating Pb toxicity.
- Evidence suggests potential therapeutic benefits for Pb intoxication.
Conclusions:
- Antioxidant supplementation (spirulina, curcumin, garlic, vitamin C, E) shows promise for managing Pb toxicity.
- Further research, including clinical trials, is essential to establish safe and effective dosages and understand long-term effects.
- Elucidating molecular mechanisms and interactions with chelating agents is necessary for enhanced therapeutic strategies.
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