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Updated: Jun 13, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Recent Advances in Microenvironment-Responsive Materials for Periodontitis Therapy.

Wenhan Ma¹, Yutong Han¹, Tong Cui¹

¹School of Stomatology, Jinan University, Guangzhou 510632, China.

International Journal of Molecular Sciences

|June 12, 2026

Summary

Intelligent biomaterials offer new precision therapies for periodontitis by responding to the disease microenvironment. These advanced materials target drug delivery for better treatment outcomes and tissue regeneration.

Keywords:

clinical translation microenvironment-responsive materials pathological microenvironment periodontitis spatiotemporal orchestration

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Last Updated: Jun 13, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

Biomaterials Science
Periodontology
Drug Delivery Systems

Background:

Periodontitis is a prevalent chronic inflammatory disease causing significant tissue destruction.
Current treatments like mechanical debridement and antibiotics have limitations in biofilm removal and drug efficacy.
There is a need for advanced therapeutic strategies to overcome these limitations.

Purpose of the Study:

To review recent advances in intelligent biomaterials for periodontitis treatment.
To explore microenvironment-responsive strategies for targeted drug delivery.
To provide a roadmap for developing next-generation precision therapies for periodontitis.

Main Methods:

Review of material platforms including hydrogels, microneedles, and nanoparticles.
Analysis of responsive designs based on pH, ROS, and enzymatic triggers.
Examination of spatiotemporal functional orchestration for different disease stages.

Main Results:

Intelligent biomaterials can modulate the pathological microenvironment of periodontitis.
Responsive strategies enable precise, on-demand drug delivery at the lesion site.
Integration of material platforms, responsive design, and functional orchestration is key.

Conclusions:

Intelligent biomaterials represent a promising approach for periodontitis precision therapy.
Addressing translational challenges like scalability and biosafety is crucial for clinical implementation.
This review offers guidance for developing advanced periodontitis treatments.