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Updated: Jun 13, 2026
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Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Mechanisms Linking Recurrent Bacterial Urinary Tract Infections to Chronic Kidney Disease Progression
Mariana-Emilia Caragea1, Daniel Cosmin Caragea2, Mohamed-Zakaria Assani1,3
1Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
International Journal of Molecular Sciences
|June 12, 2026
Summary
Recurrent urinary tract infections (UTIs) can worsen chronic kidney disease (CKD) progression. Understanding pathogen persistence and host factors is key for early detection and management of kidney injury.
Area of Science:
- Nephrology
- Infectious Diseases
- Microbiology
Background:
- Urinary tract infections (UTIs) are common bacterial infections, often considered acute.
- Emerging evidence links recurrent UTIs to the progression of chronic kidney disease (CKD).
Purpose of the Study:
- To review the pathophysiological links between UTIs caused by common uropathogens and chronic renal injury.
- To explore pathogen persistence mechanisms and host factors influencing CKD progression.
Main Methods:
- Review of literature on UTI pathogenesis and CKD development.
- Examination of uropathogenic bacteria (Escherichia coli, Klebsiella spp., Enterococcus spp.) and their persistence strategies.
- Analysis of host-related factors and emerging biomarkers.
Main Results:
- Pathogen persistence (intracellular survival, biofilms) promotes inflammation, oxidative stress, and fibrosis, leading to tubular injury.
- Host factors like diabetes and antimicrobial resistance exacerbate kidney damage.
- Biomarkers for inflammation, tubular injury, and fibrosis show promise for early detection.
Conclusions:
- Recurrent UTIs are potential contributors to CKD progression in susceptible individuals.
- Early recognition, pathogen-specific management, and improved diagnostics are crucial for mitigating renal injury.
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