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Related Experiment Video

Updated: Jun 13, 2026

FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle

FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle

Published on: June 8, 2022

Fibro-Adipogenic Progenitor Cell Alterations in Skeletal Muscle: Pathological Dysfunction or Adaptive Reprogramming?

Margarita Y Sorokina¹, Oksana A Ivanova¹, Anna A Kostareva¹

¹Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, 197341 Saint Petersburg, Russia.

International Journal of Molecular Sciences

|June 12, 2026

Summary

This summary is machine-generated.

Fibro-adipogenic progenitor cells (FAPs) in skeletal muscle change during disease and disuse. Understanding these changes in FAPs is key for developing new therapies for muscle disorders.

Keywords:

adipogenesis duchenne muscular dystrophy fibro/adipogenic progenitors metabolic flexibility myogenesis skeletal muscle skeletal muscle unloading

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Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors (FAPs) and Myogenic Progenitors (MPs) in Skeletal Muscle in the Rat

Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors (FAPs) and Myogenic Progenitors (MPs) in Skeletal Muscle in the Rat

Published on: June 9, 2021

Area of Science:

Muscle biology
Cellular and molecular medicine
Regenerative medicine

Background:

Satellite cells (SCs) and fibro-adipogenic progenitor cells (FAPs) are key skeletal muscle progenitors.
Limited data exists on how diseases and physiological conditions impact FAP biological properties.

Purpose of the Study:

To review how disuse and diseases affect FAP properties.
To explore the role of FAPs in skeletal muscle degeneration and regeneration.
To highlight FAPs as potential therapeutic targets for muscle disorders.

Main Methods:

Analysis of data from FAPs purified from skeletal muscle tissue.
Inclusion of studies on Duchenne muscular dystrophy (human and mdx mice), hindlimb unloading (rats), and type 2 diabetes (T2DM, human patients).

Main Results:

Disuse and diseases induce adaptive metabolic remodeling in FAPs.
FAP adipogenic differentiation in vitro is altered under pathological conditions.
Specific FAP subpopulations may play a role in disease development.
FAPs are involved in cell-to-cell interactions during muscle degeneration and regeneration.

Conclusions:

Physiological and pathological conditions significantly alter FAP behavior.
FAPs represent a promising target for clinical interventions in skeletal muscle disorders.
Further research is needed to elucidate FAP roles in cell-to-cell interactions for therapeutic insights.