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Related Concept Videos

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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Updated: Jun 13, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
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Published on: September 22, 2023

Roles of Metabolomics in Allergic Rhinitis: From Cell to Bedside Investigations.

Pongsathorn Saligupta1, Mongkol Lao-Araya1, Siriporn C Chattipakorn2,3,4

  • 1Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary

Metabolomics reveals metabolic changes in allergic rhinitis (AR), offering new diagnostic tools. Allergen immunotherapy (AIT) effectively modulates these metabolic disturbances, indicating therapeutic success.

Keywords:
allergen immunotherapyallergic rhinitisallergymetabolitesmetabolomics

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Area of Science:

  • Biochemistry
  • Immunology
  • Medical Diagnostics

Background:

  • Allergic diseases like allergic rhinitis (AR) exhibit metabolic pathway alterations.
  • Metabolomics presents a precise method for diagnosing allergic conditions and monitoring allergen immunotherapy (AIT).

Purpose of the Study:

  • To comprehensively review existing evidence on metabolomic changes in AR.
  • To assess the role of metabolomics in diagnosing AR and evaluating AIT efficacy.

Main Methods:

  • A PubMed database search was conducted from inception to December 2025.
  • A narrative synthesis of 16 included studies was performed.

Main Results:

  • AR involves alterations in amino acid, fatty acid, and phospholipid metabolism.
  • Fatty acids, diacylglycerols, and lysophosphatidylcholines are potential biomarkers for AR diagnosis and severity.
  • Arachidonic acid, linolenic acid, and sphingosine may indicate AIT efficacy.
  • AIT modulates the metabolic disturbances observed in AR.

Conclusions:

  • AR is characterized by specific metabolic alterations, particularly in lipid metabolism.
  • AIT demonstrates the ability to modulate these metabolic changes in AR patients.
  • Future research should integrate metabolomics with clinical and molecular data for enhanced AR management.